απο 575 PREP τοτε 5119 ADV ηρξατο 756 5662 V-ADI-3S ο 3588 T-NSM ιησους 2424 N-NSM δεικνυειν 1166 5721 V-PAN τοις 3588 T-DPM μαθηταις 3101 N-DPM αυτου 846 P-GSM οτι 3754 CONJ δει 1163 5904 V-PQI-3S αυτον 846 P-ASM απελθειν 565 5629 V-2AAN εις 1519 PREP ιεροσολυμα 2414 N-ASF και 2532 CONJ πολλα 4183 A-APN παθειν 3958 5629 V-2AAN απο 575 PREP των 3588 T-GPM πρεσβυτερων 4245 A-GPM και 2532 CONJ αρχιερεων 749 N-GPM και 2532 CONJ γραμματεων 1122 N-GPM και 2532 CONJ αποκτανθηναι 615 5683 V-APN και 2532 CONJ τη 3588 T-DSF τριτη 5154 A-DSF ημερα 2250 N-DSF εγερθηναι 1453 5683 V-APN
Vincent's NT Word Studies
21. From that time began (apo tote hrxato). He had not shown it to them before.Must (dei). It was necessary in fulfilment of the divine purpose. See Matt. xxvi. 54; Heb. viii. 3; Luke xxiv. 26.
Suffer. This first announcement mentions this passion and death generally; the second (xvii. 22, 23), adds his betrayal into the hands of sinners; the third (xx. 17-19), at length expresses his stripes, cross, etc. Elders and chief priests and scribes. A circumstantial way of designating the Sanhedrim, or supreme council of the Jewish nation.
Robertson's NT Word Studies
16:21 {From that time began} (apo tote erxato). It was a suitable time for the disclosure of the greatest secret of his death. It is now just a little over six months before the cross. They must know it now to be ready qen. The great confession of Peter made this seem an appropriate time. He will repeat the warnings (#17:22f. with mention of betrayal; #20:17-19 with the cross) which he now "began." So the necessity (dei, must) of his suffering death at the hands of the Jerusalem ecclesiastics who have dogged his steps in Galilee is now plainly stated. Jesus added his resurrection "on the third day" (tei tritei hemerai), not "on the fourth day," please observe. Dimly the shocked disciples grasped something of what Jesus said.